Computer simulation studies on the interactions between nanoparticles and cell membrane

作     者：TIAN Fa Lin YUE Tong Tao LI Ye ZHANG Xian Ren 

作者机构：State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology State Key laboratory of Heavy Oil Processing Center for Bioengineering and BiotechnologyChina University of Petroleum (East China) 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2014年第57卷第12期

页      面：1662-1671页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 08[工学] 080203[工学-机械设计及理论] 0802[工学-机械工程] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the State Key Laboratory of Chemical Engineering(SKL-CHE-12B02) the National Natural Science Foundation of China(21276007) 

主　　题：dissipative particle dynamics coarse grained molecular dynamics membrane-nanoparticle interaction endocytosis penetration 

摘      要：In recent times,nanoparticles(NPs)have received intense attention not only due to their potential applications as a candidate for drug delivery,but also because of their undesirable effects on human *** extensive experimental studies have been carried out in literature in order to understand the interaction between NPs and a plasma membrane,much less is known about the molecular details of the interaction mechanisms and *** complimentary tools,coarse grained molecular dynamics(CGMD)and dissipative particle dynamics(DPD)simulations have been extensively used on the interaction mechanism and evolution *** the present review we summarize computer simulation studies on the NP-membrane interaction,which developed over the last few years,and particularly evaluate the results from the DPD *** studies undoubtedly deepen our understanding of the NP-membrane interaction mechanisms and provide a design guideline for new NPs.