Suppressor of cytokine signaling 1 protects rat pancreatic islets from cytokine-induced apoptosis through Janus kinase/signal transducers and activators of transcription pathway

作     者：Sun Qi Xiang Ruo-lan Yang Yan-li Feng Kai Zhang Kui Ding Wen-yi 

作者机构：Chinese Acad Med Sci Peking Union Med Coll Hosp Minist Hlth Dept EndocrinolKey Lab Endocrinol Beijing 100730 Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Internal Med Beijing 100730 Peoples R China Peking Univ Hlth Sci Ctr Sch Basic Med Sci Dept Physiol & PathophysiolKey Lab Mol Cardiovas Beijing 100191 Peoples R China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2013年第126卷第21期

页      面：4048-4053页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：supported by grants from Natural Science Foundation of Beijing National Key Program of Clinical Science 

主　　题：pancreatic fl-cell cytokine apoptosis SOCS1 JAK/STAT 

摘      要：Background Suppressor of cytokine signaling （SOCS） proteins are inhibitors of cytokine signaling pathway involved in negative feedback loops. Although SOCS1 is an important intracellular suppressor of apoptosis in a variety of cell types, its role in cytokine-induced pancreatic β-cell apoptosis remains unclear. The present study investigated potential effects of SOCS1 on the cytokine-induced pancreatic β-cell apoptosis.