Chronic exercise training versus acute endurance exercise in reducing neurotoxicity in rats exposed to lead acetate

作     者：Mohammad Shahandeh Valiollah Dabidi Roshan Somayeh Hosseinzadeh Soleiman Mahjoub Vaginak Sarkisian 

作者机构：L.Orbeli Inst.of PhysiologyNAS of Armenia College of Physical Education and Sport SciencesDepartment of Sport PhysiologyUniversity of Mazandaran Babol University of Medical Sciences Department of Biochemistry and BiophysicsFaculty of MedicineBabol University of Medical Sciences 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第8期

页      面：714-722页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 

主　　题：neural regeneration neurorehabilitation long-term exercise training endurance exercise treadmill lead poisoning neurotoxicity oxidative stress hippocampus brain-derived neurotrophic factor neuroregeneration 

摘      要：After intraperitoneal injection of 20 mg/kg lead acetate, rats received 8 weeks of treadmill exercise （15-22 m/min, 25-64 minutes） and/or treadmill exercise at 1.6 km/h until exhaustion. The markers related to neurotoxicity were measured by enzyme-linked immunosorbent assay method. 8 weeks of treadmill exercise significantly increased brain-derived neurotrophic factor level in the hippocampus （P = 0.04） and plasma level of total antioxidant capacity of rats exposed to lead acetate （P 〈 0.001）, and significantly decreased plasma level of malondialdehyde （P 〈 0.001）. Acute exercise only decreased the hippocampal malondialdehyde level （P = 0.09） and increased brain-derived neurotrophic factor level in the hippocampus （P = 0.66）. Acute exercise also enhanced the total antioxidant capacity in rats exposed to lead acetate, insignificantly （P = 0.99）, These findings suggest that chronic treadmill exercise can significantly decrease neurotoxicity and alleviate oxidative stress in rats exposed to lead acetate. However, acute endurance exercise was not associated with these beneficial effects.