Polylactic Acid Nanoparticles Targeted to Brain Microvascular Endothelial Cells

作     者：王华芳 胡豫 孙望强 谢长生 

作者机构：Institute of Hematology Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Nano Pharmaceutical Research Center Huazhong University of Science & Technology Wuhan 430074 China 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2005年第25卷第6期

页      面：642-644页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina(No.30170392and50271029) 

主　　题：polylactic acid nanoparticles, polysorbate brain microvascular endothelial cells targeting 

摘      要：In this work, blank polylactic acid （PLA） nanoparticles with unstained surface were prepared by the nano-deposition method. On the basis of the preparation, the effect of surface modification on brain microvascular endothelial cells （BMECs） targeting was examined by in vivo experiments and fluorescence microscopy. The results showed that PLA nanoparticles are less toxic than PACA nanoparticles but their BMECs targeting is similar to PACA nanoparticles. The experiments suggest that drugs can he loaded onto the particles and become more stable through adsorption on the surface of PLA nanoparticles with high surface activity. The surface of PLA nanoparticles was obviously modified and the hydrophilicity was increased as well in the presence of non-ionic surfactants on PLA nanoparticles. As a targeting moiety, polysobate 80 （T-80） can facilitate BMECs targeting of PLA nanoparticles.