Comparison of nonhuman primates identified the suitable model for COVID-19

作     者：Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng Shuaiyao Lu;Yuan Zhao;Wenhai Yu;Yun Yang;Jiahong Gao;Junbin Wang;Dexuan Kuang;Mengli Yang;Jing Yang;Chunxia Ma;Jingwen Xu;Xingli Qian;Haiyan Li;Siwen Zhao;Jingmei Li;Haixuan Wang;Haiting Long;Jingxian Zhou;Fangyu Luo;Kaiyun Ding;Daoju Wu;Yong Zhang;Yinliang Dong;Yuqin Liu;Yinqiu Zheng;Xiaochen Lin;Li Jiao;Huanying Zheng;Qing Dai;Qiangming Sun;Yunzhang Hu;Changwen Ke;Hongqi Liu;Xiaozhong Peng

作者机构：National Kunming High-level Biosafety Primate Research CenterInstitute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeYunnanChina State Key Laboratory of Medical Molecular BiologyDepartment of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijingChina Medical Key Laboratory for Repository and Application of Pathogenic MicrobiologyGuangdong Provincial Center for Disease Control and PreventionGuangzhouChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2020年第5卷第1期

页      面：1102-1110页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Research and Development Project of China(2020YFC0841100,2020YFC0846400,and 2020YFA0707600) CAMS Innovation Fund for Medical Sciences(2016-I2M-2-006 and 2020-I2M-CoV19-012) the Talents Project of Yunnan Province(2017HB068) the Special Funds for High-level Health and Family Planning Technical Personnel training of Yunnan Province(D-201653) 

主　　题：acute respiratory COV 

摘      要：Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains ***,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(***)and Macaca fascicularis(***)and New World monkey Callithrix jacchus(***).Infected *** and *** showed abnormal chest radiographs,an increased body temperature and a decreased body *** genomes were detected in swab and blood samples from all *** load was detected in the pulmonary tissues of *** and *** but not ***,among the three animal species,*** showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary ***,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified *** as the most suitable for modeling COVID-19.