Photodynamic therapy in cancer treatment - an update review

作     者：Ancély Ferreira dos Santos Daria Raquel Queiroz de Almeida Leticia Ferreira Terra Mauricio S.Baptista Leticia Labriola 

作者机构：Department of BiochemistryChemistry InstituteUniversity of São PauloSão Paulo 05508-000Brazil 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2019年第4卷第3期

页      面：131-150页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：CAPES  CNPq and FAPESP (2017/03618-6  2016/04676-7 and 2013/07937-8) 

主　　题：Photodynamic therapy breast cancer photosensitizers cell death 

摘      要：Cancer remains a worldwide health problem, being the disease with the highest impact on global health. Even with all the recent technological improvements, recurrence and metastasis still are the main cause of death. Since photodynamic therapy (PDT) does not compromise other treatment options and presents reduced long-term morbidity when compared with chemotherapy or radiotherapy, it appears as a promising alternative treatment for controlling malignant diseases. In this review, we set out to perform a broad up-date on PDT in cancer research and treatment, discussing how this approach has been applied and what it could add to breast cancer therapy. We covered topics going from the photochemical mechanisms involved, the different cell death mechanisms being triggered by a myriad of photosensitizers up to the more recent-on-going clinical trials.