Effectiveness and Safety Evaluation of Chinese Medicine in Treatment of Metastatic Colorectal Cancer after Chemotherapy Failure: Protocol of a Prospective Multicenter Cohort Study

作     者：HAO Teng-teng XU Yun CUI Ning QU Qian LIANG Bi-yan YUAN Ju-hua ZHAO Yang LI Qing-na LU Fang WU Yu HAO Teng-teng;XU Yun;CUI Ning;QU Qian;LIANG Bi-yan;YUAN Ju-hua;ZHAO Yang;LI Qing-na;LU Fang;WU Yu

作者机构：Department of OncologyXiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Chinese Mdeicine Center for AIDS Prevention and TreatmentChina Academy of Chinese Medical SciencesBeijing(100700)China Department of OncologyBeijing Hospital of Integrated Traditional Chinese and Western MedicineBeijing(100039)China Institute of Clinical PharmacologyXiyuan HospitalChina 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2021年第27卷第9期

页      面：674-679页

核心收录：

学科分类：1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Beijing Municipal Commission of Science and Technology (No. D161100005116002) 

主　　题：colorectal cancer conventional chemotherapy complementary therapy Chinese medicine effectiveness 

摘      要：Background:Colorectal cancer(CRC)is the second most common cause of cancer-related deaths and has the third highest incidence in the *** half of the patients with CRC have metastases at the time of ***,the treatment for patients with metastatic CRC that progresses after approved conventional chemotherapy is still *** medicine(CM)has unique characteristics and advantages in treating metastatic ***:To assess the effectiveness and safety of CM in patients with metastatic CRC after failure of conventional ***:The study is a multicenter prospective cohort study.A total of 384 patients with documented metastatic CRC after failure of conventional chemotherapy will be included from 9 hospitals at Beijing,Shanghai,Nanjing,and Guizhou,and assigned to three groups according to paitents wishes:(1)integrated Chinese and Western medicine(ICM)group receiving CM herbal treatment combined with Western medicine(WM)anti-tumor therapy,(2)Chinese medicine(CM)group receiving only CM herbal treatment,and(3)WM group receiving only WM anti-tumor *** primary endpoint is the overall survival(OS).Secondary endpoints include the progression free survival(PFS),quality of life(QOL)assessed by the Functional Assessment of Cancer Therapy-Colorectal(FACT-C)questionnaire,tumor control,and CM symptom ***:This prospective study will assess the effectiveness and safety of CM in treating metastatic CRC after conventional chemotherapy *** in the ICM group will be compared with those in the WM group and CM *** certified to be effective,national provision of CM treatment in metastatic CRC will probably be advised.(Registration ***02923622).