Gut microbiota and diabetes: From correlation to causality and mechanism

作     者：Wei-Zheng Li Kyle Stirling Jun-Jie Yang Lei Zhang 

作者机构：Microbiome-XBeijing Advanced Innovation Center for Big Data-Based Precision MedicineSchool of Medicine and EngineeringKey Laboratory of Big Data-Based Precision MedicineBeihang UniversityBeijing 100191China School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Luddy School of InformaticsComputing and EngineeringIndiana UniversityBloomingtonIN 47408United States The Crisis Technologies Innovation LabIndiana UniversityThe Information Technology Services and the Pervasive Technology InstituteBloomingtonIN 47408United States Shandong Institute of Industrial Technology for Health Sciences and Precision MedicineJinan 250000Shandong ProvinceChina College of Life ScienceQilu Normal UniversityJinan 250000Shandong ProvinceChina Microbiome Research CenterShandong Institutes for Food and Drug ControlJinan 250000Shandong ProvinceChina Shandong Children’s Microbiome CenterQilu Children's Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Microbiological LaboratoryLin Yi People’s HospitalLinyi 276000Shandong ProvinceChina Qingdao Human Microbiome CenterThe Affiliated Central Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Institute for Medical DataologyCheeloo College of MedicineShandong UniversityJinan 250000Shandong ProvinceChina Department of BiostatisticsSchool of Public HealthCheeloo College of MedicineShandong UniversityJinan 250000Shandong ProvinceChina Shandong Children’s Microbiome CenterResearch Institute of PediatricsQilu Children's HospitalCheeloo College of MedicineShandong Universityand Jinan Children's HospitalJinan 250022Shandong ProvinceChina 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2020年第11卷第7期

页      面：293-308页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Shandong Provincial Key Research and Development Program,No.2018CXGC1219 City of Weihai Technique Extension Project,No.2016GNS023 TaiShan Scholars Program of Shandong Province,No.tshw20120206 TaiShan Industrial Experts Program,No.tscy20190612 

主　　题：Diabetes Microbiota Causality Mechanism Type 1 diabetes Type 2 diabetes Insulin resistance Inflammation Metabolites 

摘      要：In this review,we summarize the recent microbiome studies related to diabetes disease and discuss the key findings that show the early emerging potential causal roles for *** a global scale,diabetes causes a significant negative impact to the health status of human *** review covers type 1 diabetes and type 2 *** examine promising studies which lead to a better understanding of the potential mechanism of microbiota in diabetes *** appears that the human oral and gut microbiota are deeply interdigitated with *** is that *** studies of the human microbiome are capturing the attention of scientists and healthcare practitioners worldwide by focusing on the interplay of gut microbiome and *** studies focus on the role and the potential impact of intestinal microflora in *** paint a clear picture of how strongly microbes are linked and associated,both positively and negatively,with the fundamental and essential parts of diabetes in *** microflora seems to have an endless capacity to impact and transform *** conclude that there is clear and growing evidence of a close relationship between the microbiota and diabetes and this is worthy of future investments and research efforts.