Introduction to this special issue“Breast Cancer Metastasis”

作     者：William P.Schiemann William P. Schiemann

作者机构：Case Comprehensive Cancer CenterCase Western Reserve UniversityClevelandOH 44106USA 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2020年第6卷第1期

页      面：6-9页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：CA236273 

主　　题：diagnosis annually unchanged 

摘      要：Breast cancer remains the most common malignancy and most frequent cause of cancer-related death in women,a devasting reality that annually claims more than 600,000 lives across the globe[1].The vast majority of deaths due to breast cancer are attributed to metastasis and its associated relapse[2,3],which typically transpires in patients~5-20 years after their initial diagnosis[4].Although metastasis is the most lethal characteristic of breast cancer,our understanding of the molecular mechanisms that govern this event remains incomplete,a stark reality reinforced by the finding that diagnosis of distant-stage disease has remained unchanged over the course of the last two decades[5].