Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis

作     者：John R.Speakman John R.Speakman

作者机构：State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Institute of Biological and EnvironmentalSciences University of Aberdeen CAS Center of Excellence in Animal Evolution and Genetics Kunming Institute of Zoology Chinese Academy of Sciences 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2020年第7卷第7期

页      面：1153-1156页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学] 

基　　金：supported by the National Natural Science Foundation of China (91731303 and91649108) the Royal Society (Wolfson Merit Award) the Biotechnology and Biological Sciences Research Council of the UK (BB/P009875/1) the KC Wong Education Foundation and the Chinese Academy of Sciences (XDB 13030100) 

主　　题：SHORT-TERM CALORIE DIETARY RESTRICTION PROTEIN RESTRICTION GRADED-LEVELS LONGEVITY SURVIVAL IMPACT RETARDATION EVOLUTION RODENTS 

摘      要：The disposable soma hypothesis explanation of the effects of caloric restriction(CR) on lifespan fails to explain why CR generates negative impacts alongside the positive effects and does not work in all species. I propose here a novel idea called the clean cupboards hypothesis which overcomes these problems.