Diagnostic value of liquid-based cytology and smear cytology in pancreatic endoscopic ultrasound-guided fine needle aspiration: A meta-analysis

作     者：Hang-Hai Pan Xin-Xin Zhou Fei Zhao Hui-Yan Chen Yu Zhang 

作者机构：Department of GastroenterologyZhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of GastroenterologyThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina School of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第14期

页      面：3006-3020页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the Natural Science Foundation of Zhejiang Province,No.LQ20H160061 Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2018255969 

主　　题：Liquid-based cytology Smear cytology Pancreatic lesions Endoscopic ultrasound-guided fine needle aspiration Cytological diagnosis ROC curve 

摘      要：BACKGROUND Smear cytology(SC)using endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)is the established and traditional choice for diagnosing pancreatic ***-based cytology(LBC)is a novel alternative cytological method,however,the comparative diagnostic efficacy of LBC remains *** To examine the diagnostic efficacy of LBC and SC for pancreatic specimens obtained through EUS-FNA via a systematic review and *** A systematic literature search was performed using PubMed,EMBASE,the Cochrane Library,and Web of *** numbers of true positives,false positives,true negatives,and false negatives for each cytological test(LBC and CS)were extracted from the included *** pooled sensitivity and specificity and the area under the summary receiver operating characteristic curve(AUC)were calculated,and the AUC was compared by Tukey s multiple comparisons *** quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies II *** A total of 1656 patients in eight studies were *** pooled sensitivity and specificity and the AUC for LBC were 0.76(95%CI:0.72-0.79),1.00(95%CI:0.98-1.00),and 0.9174,respectively,for diagnosing pancreatic *** pooled estimates for SC were as follows:Sensitivity,0.68(95%CI:0.64-0.71);specificity,0.99(95%CI:0.96-100.00);and AUC,***,the corresponding values for LBC combined with SC were 0.87(95%CI:0.84-0.90),0.99(95%CI:0.96-1.00),and ***’s multiple comparisons test was used to compare the sensitivities and AUCs of the three diagnostic methods;statistically significant differences were found between the three methods,and LBC combined with SC was superior to both LBC(P0.05)and SC(P0.05).The pooled sensitivity and AUC did not change significantly in the sensitivity *** LBC may be sensitive than SC in the cytological diagnosis of pancreatic lesions,however,the superior diagnostic performance o