The role of histone methylation in the development of digestive cancers:a potential direction for cancer management
作者机构：Department of General SurgeryPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical College100023 BeijingPR China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：1226-1238页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Nature Science Foundation of China(2019,81972321 to L.Y 2019,81974376 to Y.P.Z.)
主 题：invasion mortality digestive
摘 要：Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and *** methylation,which is mediated mainly by lysine methyltransferases,lysine demethylases,and protein arginine methyltransferases,has emerged as an essential mechanism regulating pathological processes in digestive *** certain conditions,aberrant expression of these modifiers leads to abnormal histone methylation or demethylation in the corresponding cancer-related genes,which contributes to different processes and phenotypes,such as carcinogenesis,proliferation,metabolic reprogramming,epithelial–mesenchymal transition,invasion,and migration,during digestive cancer *** this review,we focus on the association between histone methylation regulation and the development of digestive cancers,including gastric cancer,liver cancer,pancreatic cancer,and colorectal cancer,as well as on its clinical application prospects,aiming to provide a new perspective on the management of digestive cancers.
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