Chemical comparison of Semen Euphorbiae and Semen Euphorbiae Pulveratum by UPLC-Q-TOF/MS coupled with multivariate statistical techniques

作     者：Huinan Wang Jingzhen Zhang Yuexin Cui Siyu Wang Hui Gao Yao Zhang Xinjie Wang Ziye Yang Mengyu Chen Peihua Wang Guimei Zhang Yingzi Wang Chao Zhang 王慧楠;张景珍;崔曰新;王思雨;高慧;张瑶;王新杰;杨子烨;陈梦雨;王佩华;张桂梅;王英姿;张超

作者机构：School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China School of Pharmaceutical SciencesShandong University of Traditional Chinese MedicineJinan 250355China 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2020年第29卷第7期

页      面：470-479页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Beijing Natural Science Foundation(Grant No.7182097) National Natural Science foundation of China(Grant No.81673597) National Key Research and Development Program of China(Grant No.2018YFE0197900) 

主　　题：Semen Euphorbiae Semen Euphorbiae Pulveratum UPLC-Q-TOF/MS Multivariate statistical techniques Chemical constituents Manufacturing pulveratum 

摘      要：In the present study,we aimed to assess the chemical composition changes of Semen Euphorbiae(SE)and Semen Euphorbiae Pulveratum(SEP)by UPLC-Q-TOF/MS and multivariate statistical *** UPLC-Q-TOF/MS method and SIMCA-P software were used to analyze the changes of chemical components of SE and SEP based on PCA and PLS-DA multivariate statistical methods.Acomponent-target-diseasenetwork model was constructed by Intelligent Platform for Life Sciences of traditional Chinese medicine(TCM)to predict potential related *** differences of chemical composition were significant between SE and *** positive ion mode,the amounts of Euphorbia factor L2,L3,L7a,L8,L9 and lathyrol were obviously decreased after *** negative ion mode,the amounts of aesculetin,bisaesculetin,ingenol and cetylic acid were increased obviously,while Euphorbia factor L1,L4 and L5 were decreased obviously after processing,and the components of euphobiasteroid,aesculetin,lathyrol and linoleic acid among the 14 differentiated compounds were closely related to the SE-related diseases through thecomponent-target-diseasenetwork ***-Q-TOF/MS technology in combination with multivariate statistical methods had certain advantages in studying the complex changes of chemical composition before and after manufacturing pulveratum of *** provided a basis for clarifying the toxicity-attenuated mechanisms of SE manufacturing pulveratum,and laid the foundation for its further development and utilization.