Crystal structure of SARS-CoV-2 nsp10/nsp162′-O-methylase and its implication on antiviral drug design

作     者：Sheng Lin Hua Chen Fei Ye Zimin Chen Fanli Yang Yue Zheng Yu Cao Jingxin Qiao Shengyong Yang Guangwen Lu Sheng Lin;Hua Chen;Fei Ye;Zimin Chen;Fanli Yang;Yue Zheng;Yu Cao;Jingxin Qiao;Shengyong Yang;Guangwen Lu

作者机构：West China Hospital Emergency Department(WCHED)State Key Laboratory of Biotherapy and Cancer CenterWest China Hospital and Collaborative Innovation Center of BiotherapySichuan University610041 ChengduSichuanChina Disaster Medicine CenterWest China HospitalSichuan University610041 ChengduSichuanChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2020年第5卷第1期

页      面：1251-1254页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the special research fund on COVID-19 of Sichuan Province(grant No.2020YFS0010) the special research fund on COVID-19 of West China Hospital Sichuan University(grant No.HX-2019-nCoV-004) 

主　　题：infection drugs intensified 

摘      要：Dear Editor,The unexpected outbreak of a novel human coronavirus infection has imposed great threat to public *** far,this newly-identified virus has spread to 215 countries and territories,infected more than 3.5 million people,and caused over 240,000 deaths worldwide.1 Although intensified countermeasures have been implemented globally to control the virus infection,the pandemic is still surging with a daily increase in infection case of over 65,000 ever since April 1st 2020.1 No prophylactic vaccines or clinical drugs are currently available to prevent or treat the disease,namely coronavirus disease 2019(COVID-19).