Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT

作     者：Wei Shao Chuang Yang Fangyuan Li Jiahe Wu Nan Wang Qiang Ding Jianqing Gao Daishun Ling Wei Shao;Chuang Yang;Fangyuan Li;Jiahe Wu;Nan Wang;Qiang Ding;Jianqing Gao;Daishun Ling

作者机构：Institute of Pharmaceutics and Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058ZhejiangPeople’s Republic of China Jiangsu Breast Disease CenterThe First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029JiangsuPeople’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2020年第12卷第11期

页      面：25-38页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学] 

基　　金：the financial support provided by the National Key Research and Development Program of China(2016YFA0203600) the Natural Science Foundation of China(NSFC)Project(31822019,51703195,91859116,81430040,81571738) the One Belt and One Road International Cooperation Project from Key Research and Development Program of Zhejiang Province(2019C04024) the National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”,China(2018ZX09711002) the Zhejiang Provincial Natural Science Foundation of China(LGF19C100002) the Fundamental Research Funds for the Central Universities(2019XZZX00415,2020FZZX001-05) the Leading Talent of“Ten Thousand Plan”-National High-Level Talents Special Support Plan 

主　　题：Molecular design Isoindigo Conjugated small molecule nanoparticles Singlet-triplet energy gap Synergistic PTT/PDT 

摘      要：Simultaneous photothermal therapy(PTT)and photodynamic therapy(PDT)is beneficial for enhanced cancer therapy due to the synergistic *** materials developed for synergistic PTT/PDT are generally multicomponent agents that need complicated preparation procedures and be activated by multiple laser *** emerging monocomponent diketopyrrolopyrrole(DPP)-based conjugated small molecular agents enable dual PTT/PDT under a single laser irradiation,but suffer from low singlet oxygen quantum yield,which severely restricts the therapeutic ***,we report acceptor-oriented molecular design of a donor-acceptor-donor(D-A-D)conjugated small molecule(IID-ThTPA)-based phototheranostic agent,with isoindigo(IID)as selective acceptor and triphenylamine(TPA)as *** strong D-A strength and narrow singlet-triplet energy gap endow IID-ThTPA nanoparticles(IID-ThTPA NPs)high mass extinction coefficient(18.2 L g^-1 cm^-1),competitive photothermal conversion efficiency(35.4%),and a dramatically enhanced singlet oxygen quantum yield(84.0%)comparing with previously reported monocomponent PTT/PDT *** a high PTT/PDT performance of IID-ThTPA NPs achieved superior tumor cooperative eradicating capability in vitro and in vivo.