Efficacy of Rebixiao Chinese herbal tablets and Chinese formula granules in acute gout arthritis patients:a randomized,multicenter,double-blind,controlled trial

作     者：Wang Shasha Zhang Ying Dai Min Yang Min Leng Wenfei Peng Xiufeng Li Guojun Yang Jinbing Gan Jianping Zhu Fenglin Li Yanping Wu Bin Wang Shasha;Zhang Ying;Dai Min;Yang Min;Leng Wenfei;Peng Xiufeng;Li Guojun;Yang Jinbing;Gan Jianping;Zhu Fenglin;Li Yanping;Wu Bin

作者机构：Department of RheumatologyChongqing Hospital of Traditional Chinese MedicineChongqing 400021China Department of RheumatologyNo.4 Clinical Medicine School of Chengdu University of Traditional Chinese MedicineChongqing 400021China Department of PharmacyChongqing Hospital of Traditional Chinese MedicineChongqing 400021China Department of RheumatologyTraditional Chinese Medicine Hospital Dianjiang ChongqingChongqing 408300China Department of RheumatologyTraditional Chinese Medicine Hospital Yongchuan ChongqingChongqing 402160China Department of MarketingChina Resources Sanjiu Medical&Pharmaceutical Co.Ltd.Shenzhen 518000China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2020年第40卷第4期

页      面：664-673页

核心收录：

学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：grants from the Traditional Chinese Medicine Department of Chongqing Municipal Health and Family Planning commission(No.2012-1-16) National Natural Science Foundation of China(Grant no.81673724) Chongqing Science and Technology Commission(cstc2018jxj1130084 and cstc2017jxjl130033) Chongqing Hospital of Traditional Chinese Medicine Advantageous Diseases Special Fund(No.cqszyyysbz2018004) 

主　　题：Gout Arthritis Drugs,Chinese herbal Blood sedimentation C-reactive protein Randomized controlled trial 

摘      要：OBJECTIVE:To evaluate the clinical efficacy and safety of Rebixiao(RBX)Chinese herbal tablets(CHT)and Chinese formula granules(CFG)in the treatment of acute gout arthritis(AGA).METHODS:This randomized,multicenter,double-blind,controlled trial included 165 AGA patients with the damp-heat symptom pattern who were randomly divided into an RBX CHT group and an RBX CFG group and treated for 7 d at three *** total effective rates of the joint symptom score,Traditional Chinese Medicine(TCM)symptoms score,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)were used to evaluate the clinical *** assessments were also ***:Of the 165 enrolled patients,147 completed the clinical *** was no difference in baseline between the two *** total effective rates of the joint symptom score were 94.36%and 97.36%,and the total effective rates of the TCM symptoms score were 95.77%and 97.36%in the CFG group and CHT group,*** statistical difference was found between the two groups(P0.05).Additionally,ESR and CRP were similar in both groups(P0.05).Furthermore,treatment efficacy regarding TCM and joint symptoms,the ESR,and CRP were consistent within each center and among the different centers(P0.05).In addition,the incidence of adverse events was 4.22%and 2.63%in the CFG group and CHT group,respectively,and no difference was observed between the two groups(P0.05).CONCLUSION:RBX CFG and CHT have significant and similar efficacy in the treatment of AGA,and CFG did not increase adverse side effects.