Enhanced structural stability of adenovirus nanocapsule

作     者：Ding Weng Ziyue Karen Jiang Jing Jin Lily Wu Yunfeng Lu 

作者机构：Chemical and Biomolecular Engineering University of California at Los Angeles Tissue Engineering Laboratories VA Boston Healthcare System Department of Orthopaedic Surgery Brigham and Women's Hospital Harvard Medical School Molecular and Medical Pharmacology University of California at Los Angeles Getein Biotechnology Co. Ltd. 

出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))

年 卷 期：2014年第24卷第2期

页      面：171-174页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：supported by DTRA 

主　　题：Non-covalent nanocapsule Adenovirus Structural stability 

摘      要：Application of viral vector in gene therapy and vaccination is still limited by their structural stability, which significantly increased avoidable cost in storage and transportation. Herein a non-covalent conjugated low-pH degradable nanocapsule has been adopted to stabilize viral vectors. By utilizing a luciferase expressing adenovirus, AdCMVLuc, we succeeded in a raise of over 11 folds in AdCMVLuc’s structural stability after 12 days storage at 4 1℃.