Immune checkpoint inhibitors in malignant lymphoma: Advances and perspectives

作     者：Ningjing Lin Yuqin Song Jun Zhu Ningjing Lin;Yuqin Song;Jun Zhu

作者机构：Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2020年第32卷第3期

页      面：303-318页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Immunotherapy immune checkpoint inhibitor PD-1 blockade Hodgkin lymphoma non-Hodgkin lymphoma 

摘      要：Classical Hodgkin lymphoma(cHL) has been identified with universal genetic alterations of chromosome 9p24.1,which contains PD-L1/PD-L2 *** amplification of 9p24.1 is associated with the increased expression of PDL1 and PD-L2 on RS cells, which promotes their immune evasion, and subsequently makes cHL sensitive to PD-1 *** PD-1 inhibitors have shown significant efficacies with overall response rate(ORR) of 70%-90% in relapse/refractory(r/r) cHL and have acquired the approvals for this ***, more and more studies are conducted to investigate PD-1 blockade in earlier disease course and in combination with neo-agents or *** cHL, non-Hodgkin lymphoma(NHL) consists of numerous subtypes harboring highly biological *** a few subtypes have been shown to have genetic alteration of 9p24.1 including primary mediastinal B cell lymphoma(PMBL), gray zone lymphoma(GZL) with features intermediate between diffuse large B cell lymphoma(DLBCL) and cHL, primary central nervous system lymphoma(PCNSL) and primary testicular lymphoma(PTL).Epstein-Barr virus(EBV)-associated lymphomas have a virally mediated overexpression of PD-L1, also making them sensitive to PD-1 ***, PD-1 inhibitors are less effective in most r/r NHL than in r/r *** understanding of the biological features of NHL and immune checkpoint inhibitors(ICPi) combined therapy is the research focus in the *** this review, we outlined the recent progress of ICPi in lymphoma originating from clinical studies.