Younger age of onset and multiple primary lesions associated with esophageal squamous cell carcinoma cases with a positive family history of the cancer suggests genetic predisposition

作     者：Jia Nan Wen Xiaoduo Zhang Nan YangYi Zhang Liwei Wang Xiaoling Wang Na Wen Denggui 

作者机构：Department of Surgery Hebei Tumor Hospital and theFourth Hospital of Hebei Medical University Shijiazhuang Hebei050011 China Department of Tumor Image Hebei Tumor Hospital and theFourth Hospital of Hebei Medical University Shijiazhuang Hebei050011 China Department of Medical Information Hebei Tumor Hospital and theFourth Hospital of Hebei Medical University Shijiazhuang Hebei050011 China Department of Pathology Hebei Tumor Hospital and theFourth Hospital of Hebei Medical University Shijiazhuang Hebei050011 China Department of Oncology Hebei Tumor Hospital and theFourth Hospital of Hebei Medical University Shijiazhuang Hebei050011 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第15期

页      面：2779-2783页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：esophageal squamous cell carcinoma gastric cardia adenocarcinoma a positive family history of cancer genetic predisposition onset age multiple primary cancer 

摘      要：Background Previous epidemiological studies have consistently found a positive family history of esophageal cancer is associated with a significantly increased risk of the ***,whether the elevated risk could be attributed to common household exposure or inherited susceptibility is *** study aimed to highlight the effect of genetic predisposition by noting the significant differences in onset age and multiple primary cancers between esophageal squamous cell carcinoma （ESCC） cases with or without a positive family history of the *** Age at onset and the percentage of multiple primary cancers were compared between ESCCs with （n=766） or without （n=1 776） a positive family history of the cancer in a consecutive surgery cohort at the Department of Thoracic Surgery of Hebei Tumor Hospital and the Fourth Hospital of Hebei Medical *** Overall,ESCCs with a positive family history of the cancer featured both a significantly younger age of onset and significantly more multiple primary cancers than those with a negative family history （onset age 51.83 vs.53.49 years old,P 〈0.01; percent of multiple primary cancers 5.50% vs.1.70%,x2=25.42,P 〈0.01）.Both the differences were evident in subgroup analyses,but did not *** age at onset differed significantly by family history among the male,smoking,and drinking groups,the difference of multiple primary cancers was significant among the otherwise nonsmoking,nondrinking,and younger onset age *** Younger age of onset and multiple primary cancers associated with ESCCs with a positive,as opposed to a negative family history of the cancer,suggest a genetic *** results of subgroup analyses indicate a younger age of ESCC development results from the interaction of environmental and genetic risk factors,but multiple primary cancers may be related only to genetic predisposition.