A Randomized Longitudinal Double-Blind Clinical Trial on Long-Term Neuropathic Symptomatology Relief &Pain Analgesia
A Randomized Longitudinal Double-Blind Clinical Trial on Long-Term Neuropathic Symptomatology Relief &Pain Analgesia作者机构：Department of Signaling IELLIOS Research Center Ipswich UK Clinical Dermatology Horatio Oduber Hospital Lg Smith Blvd Orangestad Aruba
出 版 物：《Health》 (健康（英文）)
年 卷 期：2020年第12卷第7期
页 面：738-749页
学科分类：1006[医学-中西医结合] 1005[医学-中医学] 100502[医学-中医临床基础] 10[医学] 100602[医学-中西医结合临床]
主 题：Aging Pain Relief Diabetes Mellitus Neuropathy TENS Ultra-Low Energy Technologies Nanotechnology Limp Amputation Neuropathic Pain
摘 要：Diabetic neuropathic pain is one of the most difficult to treat with high levels of reoccurrence and a substantial increase with aging. It involves expensive hospitalizations, often resulting in an amputated lower limb. We explored a variety of methods treating neuropathic pain such as low-level laser, monochromatic near-infrared treatment, TENS, acupuncture and pulsed electromagnetic fields that demonstrated inconclusive, limited or temporary pain relief with minor or short-term improvements in mobility. Research conducted by ultra-low energy technologies reports pain relief and reduction of inflammation as a result of anti-oxidant electron donation transforming free radicals into stable molecules. We report the results of a randomized double blind one-year-long longitudinal clinical study on 10 diabetic mellitus (DM) subjects with chronic neuropathy, treated with ultra-low energy nanotechnology who experienced substantial long-term neuropathic pain relief. Importantly, pain analgesia and improvement in neuropathic symptomatology were not age-contingent. This contradicts past research postulating that age-accumulated inflammation and endothelial dysfunction can further exacerbate diabetic neuropathy. Importantly, a method offering age-independent, cost-effective, long-term neuropathic pain relief and increased mobility has major implications in reducing hospitalization time and overall expenses by offering a solution that enhances quality of life.
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