Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation
Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation作者机构：Department of DermatoLogy Venereology and Andrology AI-Azhar University Cairo 11884 Egypt Department of Urology Menoufiya University Cairo 32511 Egypt
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2013年第15卷第1期
页 面：138-142页
核心收录：
学科分类：090603[农学-临床兽医学] 1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 1002[医学-临床医学] 09[农学] 0906[农学-兽医学] 10[医学]
基 金：FIS 99/0425, 00/0111 Sociedad Española de Nefrología, SEN Comunidad de Madrid: 08.3/0002/1998, 08.4/0019.1/2000 Japan Health Sciences Foundation, JHSF
主 题：early ejaculation erectile dysfunction intravaginal ejaculation latencytime premature climax premature ejaculation PE rapid ejaculation tramadol
摘 要：Premature ejaculation （PE） is the most common sexual disorder. It affects 20%-30% of adult men; the aetiology of this condition has not yet been elucidated. The aim of this study is to evaluate the efficacy, safety, tolerability, undesirable effects and improved satisfaction with sexual intercourse with tramadol hydrochloride at different dosages for the treatment of PE. A total of 300 patients who presented with lifelong （primary） PE were included in this study. The study was performed for 28 weeks, in which placebo （starch tablet） was given for 4 weeks, and active ingredient （tramadol hydrochloride） was administered at different therapeutic dosages for 24 weeks. Patients were divided into three equal groups, each consisting of 100 patients. The first group （A） was given tramadol hydrochloride capsule 25 mg. The second group （B） was given tramadol hydrochloride capsule 50 mg. The third group （C） was given tramadol hydrochloride capsule 100 mg. All of the 300 participants included completed the study voluntarily. The age of the patients varied from 25 to 50 years. After the treatment period, the recorded data were collected for each group and analysed. The results showed a highly significant increase in the mean intravaginal ejaculatory latency time （IELT） in all groups compared to baseline data （P〈0.0001）. We concluded that using tramadol hydrochloride at different doses on demand for the treatment of PE is effective, safe and tolerable, with minimal undesirable effects, and approval for this indication should be souRht.
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