Comparative lipidomic analysis of S. cerevisiae cells during industrial bioethanol fermentation
Comparative lipidomic analysis of S. cerevisiae cells during industrial bioethanol fermentation作者机构：Key Laboratory of Systems Bioengineering(Ministry of Education)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China
出 版 物：《Frontiers of Chemical Science and Engineering》 (化学科学与工程前沿（英文版）)
年 卷 期：2012年第6卷第4期
页 面：461-469页
核心收录：
学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 0836[工学-生物工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 083203[工学-农产品加工及贮藏工程]
主 题：lipidomics systems biology phospholipids,stirred-tank saccharomyces cerevisiae biorefinery engi-neering
摘 要：Variations in the composition and level of phospholipids （PLs） in yeast cells during industrial ethanol fermentation processes were analyzed. A comparative lipidomic method was used to investigate the changes in total cellular PLs during continuous and fed-batch/batch processes. The phospholipid metabolism in yeast changed during both processes, mainly due to the presence of longchain poly unsaturated fatty acids （PUFA） that contained phosphatidyglycerol （PG）, phosphatidylethanolamine （PE） and phosphatidylserine （PS）. The complexity of the media affected the growth of the yeast and the membrane composition. Yeast incorporated lots of exogenous saturated and PUFAs from the feedstock during the fermentations. During the continuous fermentation, there was an increase in PLs with shorter chains as the fermentation progressed and early in process there were more longchains. During the fed-batch/batch process, the PG species increased as the fermentation progressed. This is probably due to an inositol deficiency in the earlier part of the fermentation.
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