Expression of Dickkopf-related Protein 1 in Patients with Temporomandibular Osteoarthritis after Treatment with Hyaluronic Acid
作者机构：Department of StomatologyRenmin Hospital of Wuhan UniversityWuhan430060China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2020年第40卷第3期
页 面：574-579页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This study was supported by the Project of Wuhan University for Young Teachers(No.2042018kf0145)
主 题：Dickkopf-related protein 1 temporomandibular joint disorders hyaluronic acid synovial fluid
摘 要：We previously reported that the increased expression of Dickkopf-related protein 1(DKK1)is positively related to vascular endothelial growth factor in the synovial fluid from patients with temporomandibular joint disorders(TMDs).DKK1 is involved in angiogenic activities in the TMD synovium in vitro,but the expression of DKK1 after treatment of TMD-osteoarthritis(TMD-OA)with hyaluronic acid(HA)remains *** this study,we assessed the expression of DKK1 in the synovial fluid of TMD-OA patients before and after treatment with HA via enzyme-linked immunosorbent *** also investigated the role of DKK1 in TMD-OA via immunohistochemical *** relationship between the expression of DKK1 and the clinicopathological characteristics was determined by Pearson *** results showed that the expression of DKK1 was significantly decreased after treatment with *** analyses indicated that the expression of DKK1 in the TMD-OA samples was closely correlated with mouth opening and *** findings suggest that DKK1 could play an important role in the pathogenesis and treatment of *** of the pain by HA treatment may be correlated with the decreased expression of DKK1.
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