Is reversal of endothelial dysfunction still an attractive target in modern cardiology?
Is reversal of endothelial dysfunction still an attractive target in modern cardiology?作者机构：Institute of Cardiovascular and Medical SciencesUniversity of GlasgowBritish Heart Foundation Glasgow Cardiovascular Research CentreGlasgow G12 8TAUnited Kingdom
出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)
年 卷 期：2014年第6卷第8期
页 面：824-835页
主 题：Endothelium Vascular Nitric oxide Atherosclerosis Risk factors Flow-mediated dilatation
摘 要：Although the endothelium has a number of important functions, the term endothelial dysfunction is commonly used to describe impairment in its vasodilatory capacity. There have been numerous studies evaluating the relationship between endothelial dysfunction and cardiovascular disease, however assessment of endothelial function is perhaps still primarily thought of as a research tool and has not reached widespread clinical acceptance. In this review we explore the relationship between endothelial dysfunction and cardiovascular disease, its prognostic significance, methods of pharmacological reversal of endothelial dysfunction, and ask the question, is reversal of endothelial dysfunction still an attractive target in modern cardiology?
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