Potential use of corneal confocal microscopy in the diagnosis of Parkinson's disease associated neuropathy

作     者：Ning-Ning Che Hong-Qi Yang 

作者机构：Department of NeurologyHenan Provincial People's HospitalSchool of Clinical MedicineHenan UniversityZhengzhou 450003China Department of NeurologyPeople's Hospital of Zhengzhou UniversitySchool of Clinical MedicineZhengzhou UniversityZhengzhou 450003China 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2020年第9卷第3期

页      面：344-353页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This study was supported by Henan Medical Science and Technology Project(201503153) Talent project of Henan Provincial People's Hospital(23456-4) 

主　　题：Parkinson's disease Peripheral neuropathy Corneal confocal microscopy Small fiber neuropathy 

摘      要：Parkinson s disease(PD)is a chronic,progressive neurodegenerative disease affecting about 2%-3% of population above the age of *** recent years,Parkinson s research has mainly focused on motor and non-motor symptoms while there are limited studies on neurodegeneration which is associated with balance problems and increased incidence of *** confocal microscopy(CCM)is a real-time,non-invasive,in vivo ophthalmic imaging technique for quantifying nerve damage in peripheral neuropathies and central neurodegenerative *** has shown significantly lower corneal nerve fiber density(CNFD)in patients with PD compared to healthy *** CNFD is associated with decreased intraepidermal nerve fiber density in *** review provides an overview of the ability of CCM to detect nerve damage associated with PD.