Syntheses, Crystal Structures and in vitro Anticancer Activities of Dibenzyltin Compounds Based on the N-(2-Phenylacetic acid)-aroyl Hydrazone

作     者：蒋伍玖 莫天姿 张复兴 邝代治 谭宇星 JIANG Wu-Jiu;MO Tian-Zi;ZHANG Fu-Xing;KUANG Dai-Zhi;TAN Yu-Xing

作者机构：Key Laboratory of Functional Metal-organic Compounds of Hunan ProvinceKey Laboratory of Functional Organometallic MaterialsUniversity of Hunan ProvinceCollege of Chemistry and Materials ScienceHengyang Normal UniversityHengyangHunan 421008China 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2020年第39卷第4期

页      面：673-681页

核心收录：

学科分类：07[理学] 070304[理学-物理化学(含∶化学物理)] 0703[理学-化学] 

基　　金：supported by the Hengyang Normal University College Students Innovation and Entrepreneurship Training Program(No.cxcy1944) Scientific Research Fund of Hunan Provincial Education Department of China(No.19C0279) Hengyang Normal University Industrial Supported Project(Nos.HXKJ201907,HXKJ201908,HXKJ201911,HXKJ201946,HXKJ201947) Foundation of Key Laboratory of Functional Organometallic Materials,University of Hunan Province(No.GN19K07)。 

主　　题：organotin complex hydrazine synthesis crystal structure biological activity 

摘      要：Two dibenzyltin compounds,{[C6H5O(O)C=N-N=C(Ph)COO](m-Cl-C6H4CH2)2-Sn(CH3OH)}2(1)and{[p-Me-C6H4O(O)C=N-N=C(Ph)COO](m-Cl-C6H4CH2)2Sn(CH3OH)}2(2),have been synthesized by microwave“one potreaction with benzoylhydrazine(or p-methyl benzhydrazine),phenylglyoxylic acid and di-m-chlorobenzyltin dichloride.Compound 2 contains two crystals 2a and 2b.The compounds have been characterized with IR,elemental analysis,1H,13C and 119Sn NMR spectra,H RMS.Three crystals are all binuclear molecules with a Sn2O2 four-membered ring plane,and each Sn atom center is seven-coordinated with[SnO4C2N]to form a distorted pentagonal bipyramidal configuration.In vitro antitumor activities of all compounds and carboplatin were evaluated by MTT against three human cancer cells such as NCI-H460(lung cancer cells),HepG2(liver cancer cells)and MCF7(breast cancer cells),and compound 2 exhibited better antitumor activity.