Pd-Catalyzed Dearomatization of Indole Derivatives via Intermolecular Heck Reactions
作者机构：State Key Laboratory of Organometallic ChemistryCenter for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Ling ling LuShanghai 200032China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2020年第38卷第3期
页 面：235-241页
核心收录：
学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学]
基 金：We thank MOST(2016YFA0202900),NSFC(21772219,21821002,91856201) Science and Technology Commission of Shanghai Municipality(18QA1404900) Chinese Academy of Sci-ences(XDB20000000,QYZDY-SSW-SLH012) Youth Innovation Promotion Association(2017302)of CAS for generous financial support.
主 题：conditions. Heck conclusion
摘 要：Pd-catalyzed intermolecular dearomative Heck reaction of indoles with aryl iodides is described.The challenges on both reactivity and regioselectivity are addressed by the judicious regulation of the geometric and electronic properties of the substrates.An array of indoline derivatives bearing C2-quaternary center is obtained in good to excellent yields(up to 93%)with exclusive regioselectivity under operationally simple conditions.The mechanistic proposal is supported by detailed DFT calculations.
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