Electric field-driven building blocks for introducing multiple gradients to hydrogels
作者机构：Department of OrthopedicsThe Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Bums and Plastic SurgeryEngineering Research Center of the Ministry of Education for Wound Repair TechnologyThe Affiliated Hospital of Jiangnan UniversityWuxi 214041China National Engineering Laboratory for Modern Silk&Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123China Department of OrthopedicsAffiliated Hospital of Xuzhou Medical UniversityLianyungang 222061China Department of Biomedical EngineeringTufts UniversityMedfordMA 02155USA
出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)
年 卷 期：2020年第11卷第4期
页 面：267-285页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 081702[工学-化学工艺] 1002[医学-临床医学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 0836[工学-生物工程]
基 金：We thank the National Key R&D Program of China(2016YFE0204400) National Nature Science Foundation of China(Grant Nos.81171712 and 81873995) We also thank the Social Development Program of Jiangsu Province(BE2018626,BE2019662)for support of this work
主 题：silk building blocks gradients hydrogel tissue regeneration
摘 要：Gradient biomaterials are considered as preferable matrices for tissue engineering due to better simulation of native *** introduction of gradient cues usually needs special equipment and complex process but is only effective to limited *** of multiple gradients in the hydrogels remains ***,betasheet rich silk nanofibers(BSNF)were used as building blocks to introduce multiple gradients into different hydrogel systems through the joint action of crosslinking and electric *** blocks migrated to the anode along the electric field and gradually stagnated due to the solution-hydrogel transition of the systems,finally achieving gradient distribution of the blocks in the formed *** gradient distribution of the blocks could be tuned easily through changing different factors such as solution viscosity,which resulted in highly tunable gradient of mechanical *** blocks were also aligned under the electric field,endowing orientation gradient *** cargos could be loaded on the blocks and form gradient cues through the same crosslinking-electric field *** building blocks could be introduced to various hydrogels such as Gelatin and NIPAM,indicating the *** niches with multiple gradient cues could be achieved through the ***-based hydrogels with suitable mechanical gradients were fabricated to control the osteogenesis and ***-osteogenic gradient transition was obtained,which stimulated the ectopic osteochondral tissue regeneration in *** versatility and highly controllability of the strategy as well as multifunction of the building blocks reveal the applicability in complex tissue engineering and various interfacial tissues.
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