Studies of nanoparticle delivery with in vitro bio-engineered microtissues

作     者：Mingze Sun Jinhyung Lee Yupeng Chen Kazunori Hoshino 

作者机构：Department of Biomedical EngineeringUniversity of Connecticut260 Glenbrook RdStorrsCT06269USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2020年第5卷第4期

页      面：924-937页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：NSF(CCSS-1809047,CAREER-1653702) NIH(1R01AR072027-01,1R03AR069383-01) the office of undergraduate research(OUR)at the University of Connecticut for providing funds to support this study 

主　　题：Nanoparticles Drug delivery In vitro tissue model Multicellular spheroid 

摘      要：A variety of engineered nanoparticles,including lipid nanoparticles,polymer nanoparticles,gold nanoparticles,and biomimetic nanoparticles,have been studied as delivery vehicles for biomedical *** assessing the efficacy of a nanoparticle-based delivery system,in vitro testing with a model delivery system is crucial because it allows for real-time,in situ quantitative transport analysis,which is often difficult with in vivo animal *** advent of tissue engineering has offered methods to create experimental models that can closely mimic the 3D microenvironment in the human *** review paper overviews the types of nanoparticle vehicles,their application areas,and the design strategies to improve delivery efficiency,followed by the uses of engineered microtissues and methods of *** particular,this review highlights studies on multicellular spheroids and other 3D tissue engineering approaches for cancer drug *** use of bio-engineered tissues can potentially provide low-cost,high-throughput,and quantitative experimental platforms for the development of nanoparticle-based delivery systems.