A review of rat models of periodontitis treated with natural extracts

作     者：Kim Jeong-Hyon Goo Bon-Hyuk Nam Sang-Soo Park Yeon-Cheol Kim Jeong-Hyon;Goo Bon-Hyuk;Nam Sang-Soo;Park Yeon-Cheol

作者机构：Department of Clinical Korean MedicineGraduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Department of Acupuncture&MoxibustionKyung Hee University Korean Medicine HospitalSeoul05278Republic of Korea 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2020年第7卷第2期

页      面：95-103页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Kyung Hee University(Seoul Republic of Korea)in 2018(KHU-20180922) 

主　　题：Natural extracts Periodontitis Rat models 

摘      要：Objective:To review treatment methods using natural extracts applied in rat models of periodontitis to establish a direction for the design of future ***:An electronic search of PubMed was carried out using the keywords“periodontitis,“natural,“extracts,“herb*,“plantsand“rats.Articles were screened against inclusion and exclusion criteria by two independent *** describing the characteristics of rats,method of periodontitis inducement,extract administration,and outcome measures were extracted and analyzed by more than two authors ***:Of the 864 articles identified,33 studies were *** use of SpragueeDawley rats(51.2%)and male rats(90.9%)was *** most common experimental methods were ligature placement(72.7%)and oral administration(66.7%).Alveolar bone loss was evaluated mainly by photography(51.5%)and micro-computed tomography(39.4%).Factors related to bone remodeling and inflammatory processes,such as interleukin-1b,tumor necrosis factor-a,receptor activator of nuclear factor-kB,and osteoprotegerin,were also ***:Many diverse experimental periodontitis models have been ***,few articles observed bone formation,immune responses,antibacterial effects,and *** studies to assess natural extracts for the treatment of periodontitis should be robust and well-designed.