Ever-increasing diversity of drug-induced pancreatitis

作     者：Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian 

作者机构：Department of MedicineHackensack University-Palisades Medical CenterNorth BergenNJ 07047United States Department of MedicineUniversity of Toledo Medical CenterToledoOH 43614United States Vatche and Tamar Manoukian Division of Digestive DiseasesDavid Geffen School of Medicine at UCLALos AngelesCA 90095United States Department of Interventional RadiologyJohns Hopkins University HospitalBaltimoreMD 21205United States Division of GastroenterologyDepartment of MedicineOlive View-UCLA Medical CenterSylmarCA 91342 and David Geffen School of Medicine at UCLALos AngelesCA 90095United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第22期

页      面：2902-2915页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Drug-induced pancreatitis Acute pancreatitis Pharmacology Mechanism of action Inflammation Etiology 

摘      要：With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well *** has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute ***,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription ***,the majority of available data is derived from case reports,case series,or case control ***,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic ***,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute ***,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this *** believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity.