Value of metabolic parameters in distinguishing primary mediastinal lymphomas from thymic epithelial tumors

作     者：Lei Zhu Xiaofeng Li Jian Wang Qiang Fu Jianjing Liu Wenchao Ma Wengui Xu Wei Chen Lei Zhu;Xiaofeng Li;Jian Wang;Qiang Fu;Jianjing Liu;Wenchao Ma;Wengui Xu;Wei Chen

作者机构：Department of Molecular Imaging and Nuclear MedicineTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2020年第17卷第2期

页      面：468-477页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Tianjin Science and Technology Program Fund(grant No.18 PTZWHZ00100 and H2018206600) 

主　　题：FDG PET-CT lymphoma metabolic tumor burden quantitative evaluation thymic epithelial tumors 

摘      要：Objective:A high rate of unnecessary thymectomies has been *** study aimed to distinguish primary mediastinal lymphomas(PMLs)from thymic epithelial tumors(TETs)by evaluating volumetric and metabolic parameters with l8F-FDG PET/***:A total of 136 patients who were pathologically diagnosed with TETs or PMLs were enrolled,and 18F-FDG PET/CT was performed before *** parameters,including the mean SUV(SUVmean),metabolic tumor volume(MTV),total lesion glycolysis(TLG),and SUVmax,were determined and compared between the 2 *** diagnostic performance of these parameters was evaluated with receiver operating characteristic(ROC)curve ***:All parameters significantly differed between patients with PMLs and *** with lymphomas were younger and had higher SUVmean,SUVmax,TLG,and MTV values than patients with *** MTV and TLG values had similar diagnostic *** analysis indicated that the areas under the curves of the SUVmean and SUVmax values performed similarly(approximately 0.76)in differentiating patients with PMLs from TETs,and both values were better than the MTV and TLG *** age was included with the SUVmax in differentiating TETs from PMLs,the AUC was 0.91,and the sensitivity and specificity increased to 80%and 93%,***:The SUVmax and volumetric parameters of 18F-FDG PET/CT can be used to distinguish patients with PMLs versus TETs,and thus may aid in preventing unnecessary thymectomies or other invasive operations.