Evaluation of toxicity profiles of rare earth elements salts(lanthanides)

作     者：M.Rucki K.Kejlov A.Vlkov D.Jirova M.Dvorakova L.Svobodova H.Kandarova S.Letasiova H.Kolarova M.Mannerstrom T.Heinonen M.Rucki;K.Kejlova;A.Vlkova;D.Jirova;M.Dvorakova;L.Svobodova;H.Kandarova;S.Letasiova;H.Kolarova;M.Mannerstrom;T.Heinonen

作者机构：National Institute of Public HealthSrobarova 49/4810000 Prague.Czech Republic Centre of Experimental Medicine SASSlovak Academy of SciencesDubravska Cesta 984104 Bratislava.Slovakia MatTek In Vitro Life Science LaboratoriesMlynske Nivy 7382105 BratislavaSlovakia Department of Medical BiophysicsFaculty of Medicine and DentistryPalacky UniversityHnevotinska 377515 OlomoucCzech Republic FICAMFaculty of Medicine and Health TechnologyFI-33014 Tampere UniversityTampereFinland 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：2021年第39卷第2期

页      面：225-232页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：the ERDF/ESF project“International Competitiveness of NIPH in Research,Development and Education in Alternative Toxicological Methods”(CZ.02.1.01/0.0/0.0/16019/0000860) by Ministry of Health,Czech Republic-Conceptual Development of Research Organization(National Institute of Public Health-NIPH,75010330) 

主　　题：Lanthanides Rare earth elements Local toxicity Systemic toxicity Ecotoxicity 

摘      要：The presented study aims to extend the knowledge of toxicological profile of rare earth elements salts(REEs).The basal toxicity test performed comprised assessment of cytotoxicity(3 T3 Balb/c Neutral Red Uptake Test)that allows for calculation of LD50(rats)on the basis of the concentration which leads to a50%reduction in cell growth(IC50).Environmental toxicity was addressed by the Tubifex tubifex(T.t.)express *** in vitro skin irritation(OECD TG 439)and skin corrosion tests(OECD TG 431)utilizing the 3 D in vitro reconstructed human epidermal model EpiDerm(MatTek IVSL,SK)were used for assessment of skin irritation and corrosion potential hazard of *** effects were determined using the bacterial reverse mutation assay(Ames Test)on 5 Salmonella typhimurium strains with and without metabolic activation(OECD TG 471).Endocrine disruption was evaluated by means of a yeastbased assay YES/YAS(Xenometrix,CH).Skin sensitization was assessed using the LuSens assay,based on a genetically modified human keratinocyte cell line(OECD TG 442 D).The tested REEs have no potential of mutagenicity or skin sensitization,exhibit very weak endocrine disruption potential and only exceptional local irritation/corrosion effects for thulium(Ⅲ)chloride anhydrous,but have acute and chronic toxic effects on the aquatic environment.