Temperature-sensitive polymeric nanogels encapsulating withβ-cyclodextrin and ICG complex for high-resolution deep-tissue ultrasound-switchable fluorescence imaging
作者机构：Ultrasound and Optical Imaging LaboratoryDepartment of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA Joint Biomedical Engineering Programthe University of Texas at Arlington and the University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2020年第13卷第4期
页 面：1100-1110页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
主 题：deep tissue imaging high-resolution ultrasound-switchable NIR fluorescence imaging in vivo imaging
摘 要：One of the thorny problems currently impeding the applications of the fluorescence imaging technique is the poor spatial resolution in deep ***-switchable fluorescence(USF)imaging is a novel imaging tool that has recently been explored to possibly surmount the above-mentioned ***,αβ-cyclodextrin/indocyanine green(ICG)complex-encapsulated poly(N-isopropylacrylamide)(PNIPAM)nanogel was synthesized and studied for ex vivo/in vivo deep tissue/high-resolution near infrared USF(NIR-USF)*** be specific,our results revealed that the average diameter of the as-prepared nanogels was significantly decreased to-32 nm from-335 nm compared to the reported ICG-PNIPAM ***,the excitation/emission characteristics of the ICG itself in present nanogels were almost completely retained,and the resultant nanogel exhibited high physiological stability and positive *** particular,the signal-to-noise ratio of the USF image for the PNIPAM/P-cyclodextrin/ICG nanogel(33.01±2.42 dB)was prominently higher than that of the ICG-PNIPAM nanoparticles(18.73±0.33 dB)in 1.5-cm-thick chicken breast *** NIR-USF imaging in 3.5-cm-thick chicken breast tissues was achieved using this new *** e x v iv o NIR-USF imaging of the mouse liver was also successfully *** experiments showed that the present nanogels were able to be effectively accumulated into U87 tumor-bearing mice via enhanced permeability and retention effects,and the high-resolution NIR-USF imaging of in v ivo tumor was efficiently *** metabolism and in vivo biodistribution of the nanogels were ***,the results suggest that the current nanogel is a highly promising NIR-USF probe for deep tissue and high-resolution USF imaging.
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