Fas基因启动子-670位单核苷酸腺嘌呤被鸟嘌呤取代的多态性与多胎妊娠中早产胎膜早破的关系
A single nucleotide A>G polymorphism at position-670 in the Fas gene promoter: Relationship to preterm premature rupture of fetal membranes in multifetal pregnancies作者机构：Immunology and Infectious Diseases Dept. of Obstetrics and Gynecology Weill Med. Coll. of Cornell Univ. New York NY United States Dr.
出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)
年 卷 期：2005年第1卷第6期
页 面：18-18页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
主 题：早产胎膜早破 Fas基因 多胎妊娠 启动子 鸟嘌呤 自然流产患者 单核苷酸 妊娠结局 多态性 纯合子
摘 要：The relationship between a polymorphism at position - 670 in the Fas gene (TNFRSF6) and preterm premature rupture of membranes (PPROM) in multifetal pregnancies was examined. Buccal swabs from 119 mother- infant sets were analyzed for an adenine (A) to guanine (G) substitution at position - 670 in the TNFRSF6 promoter. Pregnancy outcome data were subsequently obtained. Analysis was by Fisher exact test. Maternal allele G homozygosity (TNFRSF6* G) was observed in 42.4% of 33 PPROM pregnancies as opposed to 19.5% of 77 with no spontaneous preterm birth (P =. 01). Similarly, TNFRSF6* G homozygosity was present in 37.5% of 32 first- born neonates from PPROM pregnancies as opposed to 18.7% of 75 uncomplicated pregnancies (P =. 04). PPROM occurred in 8 of 14 (57.1% ) pregnancies in which mother and all neonates were TNFRSF6* G homozygotes as opposed to 25 of 105 (23.8% )- cases in which uniform TNFRSF6* G homozygosity was not observed (P =. 02). A genetic variant in the Fas gene is associated with an increased rate of PPROM in multifetal pregnancies.
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