PERK Signaling of Unfolded Protein Response Actived in Acute Hypobaric Hypoxia and Effect of Ginsenoside Rb1

作     者：Yun Li Hong-bo LUO Xiang-qun Shi Chun-sheng Xi Jian-kui Guo Zhi-qiang Zhang Li Cao Xiao-yan Zhang Zhao Liu 

作者机构：Department of Nephrology Lanzhou General Hospital Lanzhou Military Area Command Lanzhou 730050 China Department of Neurology Lanzhou General Hospital Lanzhou Military Area Command Lanzhou 730050 China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2016年第8卷第1期

页      面：39-43页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Natural Science Foundation of Lanzhou Military Area Command(No.CLZ13JA01) 

主　　题：ginsengoside Rbl hypobaric hypoxia pancreatic ER kinase pathway 

摘      要：Objective To observe pancreatic ER kinase （PERK） signaling of unfolded protein response （UPR）. Methods The rats were divided into control, model, and ginsenoside Rb; （Rbl） groups, and put into hypoxia chamber to establish the acute plateau stress model. The water solutions of Rbl were given to rats in Rb; group for 7 d. After that, The behavior of rats was observed by Y-maze and passive avoidance test and the rats were sacrificed in a batch for detection by Western blotting. Results Hypobaric hypoxia mediated UPR pathway accompanied the activation of protective pathways such as PERK-elF2a-ATF4 and Grp78/Bip pathways. On the other hand, RbT, the extract from herbal medicine ginseng, increased on the expression of PERK, eIF2a, ATF4, and Grp78/Bip in rats. Conclusion The results indicate that PERK-elF2a-ATF4-GRP78 pathway is a potential target for therapeutic applications in high altitude diseases and Rb] can attenuate the injury to memory function caused by hypobaric hypoxia neurotoxicity.