Bisphosphonate use and gastrointestinal tract cancer risk:Meta-analysis of observational studies

作     者：Yun Hwan Oh Chan Yoon Sang Min Park 

作者机构：Department of Family MedicineSeoul National University HospitalSeoul National University College of MedicineSeoul 110-774South Korea Seoul National University HospitalSeoul National University College of MedicineSeoul 110-774South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第40期

页      面：5779-5788页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by The Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education Science and Technology No.2012-0003761 

主　　题：胃肠道肿瘤 磷酸盐类 Meta分析 癌症 药物 风险 队列研究 MEDLINE 

摘      要：AIM:To perform a meta-analysis of observational studies to further elucidate the relationship between oral bisphosphonate use and gastrointestinal cancer ***:Systematic literature search was conducted in MEDLINE,EMBASE,and the Cochrane Library to identify studies through January *** terms were bisphosphonates or trade names of the drugs,and observational studies or cohort studies or case-control studies.Two evaluators reviewed and selected articles on the basis of predetermined selection criteria as followed:(1) observational studies(casecontrol or cohort studies) on bisphosphonate use;(2) with at least 2 years of follow-up;and(3) reported data on the incidence of cancer *** DerSimonian and Laird random effects model were used to calculate the pooled relative risk(RR) with 95% confidence interval(CI).Two-by-two contingency table was used to calculate the outcomes not suitable for *** meta-analyses were conducted for the type of cancer(esophageal,gastric and colorectal cancers).Sensitivity analyses were performed to examine the effect sizes when only studies with long-term follow-up(mean 5 years;subgroup 3 years) were ***:Of 740 screened articles,3 cohort studies and 3 case-control studies were included in the *** first,4 cohort studies and 3 case-control studies were selected for the analyses but one cohort study was excluded because the cancer outcomes were not categorized by type of gastrointestinal *** than 124 686 subjects participated in the 3 cohort *** mean follow-up time in all of the cohort studies combined was approximately 3.88 *** 3 casecontrol studies reported 3070 esophageal cancer cases and 15 417 controls,2018 gastric cancer cases and 10 007 controls,and 11 574 colorectal cancer cases and 53 955 *** percentage of study participants who used bisphosphonate was 2.8% among the cases and 2.9% among the *** meta-analysis of all the studies fo