Long-Term Fever and Cytomegalovirus Infection in the Field of HIV Immunosuppression in Two Cases and Review of the Literature

作     者：Angèle Azon-Kouanou Kouessi Anthelme Agbodande Marius Doukpo Mahoutin Semassa Ghislain Missiho Roberto Dossou Torès Kouassi Prudencio Crescent Darius Cossou-Gbéto Eugénie Dansou Djimon Marcel Zannou Fabien Houngbe Angèle Azon-Kouanou;Kouessi Anthelme Agbodande;Marius Doukpo;Mahoutin Semassa Ghislain Missiho;Roberto Dossou Torès Kouassi Prudencio;Crescent Darius Cossou-Gbéto;Eugénie Dansou;Djimon Marcel Zannou;Fabien Houngbe

作者机构：Internal Medicine and Medical Oncology Department National Teaching Hospital (NTH) Hubert Koudougou Maga (HKM) Cotonou Benin 

出 版 物：《Open Journal of Internal Medicine》 (内科学期刊（英文）)

年 卷 期：2020年第10卷第2期

页      面：151-159页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：CMV Infection HIV Deaths Cotonou 

摘      要：Cytomegalovirus (CMV) infection is an infection that most often affects immunocompromised individuals with a seroprevalence of more than 80%. CMV co-infection is associated with increased mortality in HIV-infected individuals despite antiretroviral treatment. It has the potential for hematogenous dissemination to all the organs, but only becomes symptomatic when the viral load is high. This is especially possible when the human immune system is well controlled so that the individual infected with CMV generally remains asymptomatic, and possibly for a long period. Once the immune system fails, CMV infection becomes symptomatic. Diagnosis is not easy and is often done postmortem in developing countries with limited technical facilities. We report here two cases diagnosed at the Internal Medicine Service of the CNHU-HKM in Cotonou. The patients were infected with HIV and had a long term fever. The diagnoses were made on the basis of CMV serology. The first diagnosis was post-mortem, and the second patient died 48 hours after the start of the treatment.