Calcium-mineralized polypeptide nanoparticle for intracellular drug delivery in osteosarcoma chemotherapy

作     者：Ke Li Di Li Li Zhao Yonghe Chang Yi Zhang Yan Cui Zhiyu Zhang 

作者机构：Department of OrthopedicsThe Fourth Affiliated Hospital of China Medical University4 Chongshandong RoadShenyang 110032People's Republic of China Key Laboratory of Polymer EcomaterialsChangchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022People's Republic of China Laboratory of Building Energy-Saving Technology EngineeringCollege of Material Science and EngineeringJilin Jianzhu University5088 Xincheng StreetChangchun 130118People's Republic of China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2020年第5卷第3期

页      面：721-731页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 0702[理学-物理学] 

基　　金：financially supported by the National Natural Science Foundation of China(Grant No.51803006) the Scientific Development Program of Liaoning Province(Grant No.20170541058) the China Postdoctoral Science Foundation(Grant No.2019M650297) 

主　　题：Polypeptide Calcium mineralization Controlled drug release pH-responsiveness Osteosarcoma chemotherapy 

摘      要：The acidic microenvironments of tumor tissue and cells provide an opportunity for the development of pHresponsive drug delivery systems in cancer *** this work,we designed a calcium carbonate(CaCO3)-corecrosslinked nanoparticle of methoxy poly(ethylene glycol)-block-poly(L-glutamic acid)through mineralization for intracellular delivery of doxorubicin(DOX),referred to as CaNP/***/DOX exhibited high drug loading capability,uniform nanoparticle size,and pH-dependent DOX *** the meantime,the enhanced cell uptake,superior cytotoxicity toward mouse osteosarcoma K7 cells,extended circulation half-life,and improved accumulation of DOX in K7 allograft tumor from CaNP/DOX were also *** interestingly,CaNP/DOX displayed improved antitumor effect and reduced side effects against the K7 osteosarcoma-allografted mouse model and the 143B orthotopic osteosarcoma mouse *** the superior properties of Ca-mineralized polypeptide nanoparticle for intracellular drug delivery,the smart drug delivery system showed strong competitiveness in clinical chemotherapy of cancers.