Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy

作     者：Bo Yang Shan Zhou Jie Zeng Liping Zhang Runhao Zhang Kang Liang Lei Xie Bing Shao Shaoli Song Gang Huang Dongyuan Zhao Pu Chen Biao Kong Bo Yang;Shan Zhou;Jie Zeng;Liping Zhang;Runhao Zhang;Kang Liang;Lei Xie;Bing Shao;Shaoli Song;Gang Huang;Dongyuan Zhao;Pu Chen;Biao Kong

作者机构：Department of ChemistryShanghai Key Lab of Molecular Catalysis and Innovative MaterialsiChEMFudan UniversityShanghai 200032China School of Chemical Engineering and Graduate School of Biomedical EngineeringThe University of New South WalesNSW 2052Australia Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food PoisoningBeijing Center for Disease Prevention and ControlBeijing 100013China Department of Nuclear MedicineShanghai Cancer CenterFudan UniversityShanghai 200032China Shanghai Key Laboratory of Molecular ImagingShanghai University of Medicine and Health SciencesShanghai 201318China Institute of Clinical Nuclear MedicineRenji Hospital Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Chemical EngineeringUniversity of WaterlooWaterlooOntarioN2L 3G1Canada 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2020年第13卷第4期

页      面：1013-1019页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：This work was supported by the National Key Research and Development Program of China(Nos.2019YFC1604600,2017YFA0206901,2017YFA0206900) the National Natural Science Foundation of China(Nos.21705027,21974029,81830052),the Construction project of Shanghai Key Laboratory of Molecular Imaging(No.18DZ2260400) the Shanghai Municipal Education Commission(Class II Plateau Disciplinary C onstruction Program of Medical Technology of SUMHS,2018-2020) the Australia National Health and Medical Research Council(NHMRC)(No.APP1163786) the Scientia Fellowship program at UNSW,the MCTL Visiting Fellowship Program,Shanghai Key Laboratory of Molecular Imaging(No.18DZ2260400) the Natural Science Foundation of Shanghai,and the Recruitm ent Program of Global Experts of China and Shanghai 

主　　题：pH-responsive photothermal therapy metal-polyphenol complex synergistic therapy 

摘      要：Multimodal combinatorial therapy merges different modes of therapies in one platform,which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment *** we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive *** super-assembly of mesoporous silica nanoparticles(MSN)with metal-phenolic networks(MPN),anti-cancer drugs can be loaded in the MSN matrix,while the outer MPN coating allows dual photothermal and pH-responsive *** near-infrared light irradiation,the MSN@MPN nanoplatform exhibits excellent photothermal effect,and demonstrates outstanding pH-triggered drug release *** vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer ***,the MSN@MPN system shows promising prospects in clinical application for tumor therapy.