Numerical Simulation of Fluid and Heat Transfer in a Biological Tissue Using an Immersed Boundary Method Mimicking the Exact Structure of the Microvascular Network

作     者：Yuanliang Tang Lizhong Mu Ying He 

作者机构：Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of EducationDalian University of TechnologyDalian116024China National Engineering Research Center for Healthcare DevicesGuangdong Key Lab of Medical Electronic Instruments and Polymer Material ProductsGuangdong Institute of Medical InstrumentsGuangzhou510500China 

出 版 物：《Fluid Dynamics & Materials Processing》 (流体力学与材料加工（英文）)

年 卷 期：2020年第16卷第2期

页      面：281-296页

核心收录：

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

基　　金：This study was supported by National Natural Science Foundation of China(NSFC No.51576033) Dalian Innovative Funding of Science and Technology(2018J12SN076) NSFC No 11602053 

主　　题：Bioheat transfer porous media immersed boundary method diabetes microvascular dysfunction skin temperature fluctuation 

摘      要：The aim of this study is to develop a model of fluid and heat transfer in a biological tissue taking into account the exact structure of the related microvascular network,and to analyze the influence of structural changes of such a network induced by diabetes.A cubic region representing local skin tissue is selected as the computational domain,which in turn includes two intravascular and extravascular *** save computational resources,the capillary network is reduced to a 1D pipeline model and embedded into the extravascular *** the basis of the immersed boundary method(IBM)strategy,fluid and heat fluxes across a capillary wall are distributed to the surrounding tissue nodes by a delta *** consider both steady and periodic blood pressure conditions at the entrances of the capillary *** steady blood pressure conditions,both the interstitial fluid pressure and tissue temperature around the capillary network are larger than those in other *** the periodic blood pressure condition is considered,tissue temperature tends to fluctuate with the same frequency of the forcing,but the related waveform displays a smaller amplitude and a certain time(phase)*** the connectivity of capillary network is diminished,the capacity of blood redistribution through the capillary network becomes weaker and a subset of the vessel branches lose blood flow,which further aggravates the amplitude attenuation and time delay of the skin temperature fluctuation.