Association of alcohol consumption with colorectal cancer risk: a dose-response meta-analysis

作     者：Yan Li Zhi-Li Xu Yi-Yi Cui Yong Guo 

作者机构：Departmet of Integrative OncologyThe First Affiliated Hospital of Zhejiang Chinese Medicine University54 Youdian RoadHangzhou 310006China Department of First Clinical MedicineZhejiang Chinese Medicine University548Bingwen RoadHangzhou 310053China Departmet of Integrative OncologyThe Third Affiliated Hospital of Zhejiang Chinese Medicine University219Moganshan RoadHangzhou 310013China 

出 版 物：《Food Therapy and Health Care》 (食疗与健康管理（英文）)

年 卷 期：2020年第2卷第2期

页      面：40-53页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant No:81973805) Zhejiang Provincial Project for the Key Discipline of Traditional Chinese Medicine(Yong GUO,Grant No.2017-XK-A09,http://www.zjwjw.gov.cn/) Zhejiang Provincial TCM Science and Technology Project(Grant No:2015ZA088) Project of Academic Experiences Inheritance from the Famous Traditional Chinese Medicine Doctor of Zhejiang Province,Yong Guo and Construction of Specialized Subject(Grant No.2A11543) 

主　　题：Alcohol consumption Colorectal cancer risk Dose-response Meta-analysis 

摘      要：Background:Currently,there are many meta-analyses on the correlation between alcohol conception and the risk of colorectal cancer,but the findings are *** conducted a dose-response meta-analysis to investigate the association between alcohol intake and the risk of colorectal ***:A literature search was performed on PubMed and EMBASE databases to identify relevant articles published before December 09,*** relative risks(RRs)and 95%confidence intervals(CIs)were calculated using a fixed or random-effects model for the dose-response *** Cochran Q and I2 statistics were used to assess statistical heterogeneity among ***:Five cohort and 19 case-control studies were included in the *** increased intake of 15-39.9g of daily alcohol was related to a 21%growth risk of CRC(RR=1.21,95%CI:1.05-1.38).Our dose-response analysis indicated that for drinkers of light,moderate and heavy level of alcohol drinking,the estimated RRs of CRC were 0.94(95%CI:0.69-1.27),1.08(95%CI:0.93-1.26)and 1.90(95%CI:1.29-2.97)respectively and for drinkers of moderate beer,heavy beer,moderate wine and heavy wine intake,the estimated RRs of CRC were 0.98(95%CI:0.72-1.34),1.48(95%CI:1.05-2.07),0.86(95%CI:0.56-1.34)and 1.04(95%CI:0.83-1.29)*** risks with no significant association were consistent in the subgroup analyses of general alcohol consumption status and ***:Heavy level of alcohol consumption,especially heavy beer intake seems to be associated with an increased the risk of CRC.