Advances in biosynthesis of triterpenoid saponins in medicinal plants
在药用的植物在 triterpenoid saponins 的生合成进展作者机构：Tianjin Key Laboratory for Modern Drug Delivery and High EfficiencySchool of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Key Laboratory of Systems BioengineeringMinistry of EducationTianjin UniversityTianjin 300072China
出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)
年 卷 期：2020年第18卷第6期
页 面：417-424页
核心收录：
学科分类：071011[理学-生物物理学] 0710[理学-生物学] 07[理学]
基 金：the Central Significant Increase or Decrease Program of China(No.2060302-1604-05) NSFC(No.81703639)
主 题：Medicinal plant Cytochrome P450 monooxygenases Uridine diphosphate glucuronosyltransferases Transcription factor Triterpenoid saponins
摘 要：In recent years, biosynthesis of triterpenoid saponins in medicinal plants has been widely studied because of their active ingredients with diverse pharmacological activities. Various oxidosqualene cyclases, cytochrome P450 monooxygenases, uridine diphosphate glucuronosyltransferases, and transcription factors related to triterpenoid saponins biosynthesis have been explored and identified. In the biosynthesis of triterpenoid saponins, the progress of gene mining by omics-based sequencing, gene screening, gene function verification, catalyzing mechanism of key enzymes and gene regulation are summarized and discussed. By the progress of the biosynthesis pathway of triterpenoid saponins, the large-scale production of some triterpenoid saponins and aglycones has been achieved through plant tissue culture, transgenic plants and engineered yeast cells. However, the complex biosynthetic pathway and structural diversity limit the biosynthesis of triterpenoid saponins in different system. Special focus can further be placed on the systematic botany information of medicinal plants obtained from omics large dataset, and triterpenoid saponins produced by synthetic biology strategies, gene mutations and gene editing technology.
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