Nogo-A and the regulation of neurotransmitter receptors

作     者：Bor Luen Tang 

作者机构：Department of BiochemistryYong Loo Lin School of MedicineNational University of Singapore Graduate School for Integrative Sciences and EngineeringNational University of SingaporeSingapore 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第11期

页      面：2037-2038页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学] 

基　　金：supported by the NUS Graduate School for Integrative Sciences and Engineering 

主　　题：restrict likely limiting 

摘      要：Nogo-A is known to restrict plasticity in the adult central nervous system,and signalling through its cognate receptors modulates synaptic spine architecture and excitatory glutamate transmission via restricting synaptic glutamate receptor levels and their delivery to the post-synaptic compartments.A recent report now indicates that Nogo-A,signaling through Sphingosine-1-Phosphate Receptor 2,also strengthens inhibitory gamma amino acid butyric acid(GABA)ergic transmission by limiting the diffusion dynamics of GABAA receptors.This reciprocal modulation of excitatory and inhibitory signaling via neurotransmitter receptor dynamics by Nogo-A likely plays important pathophysiological roles in synaptic plasticity during development and injury.