Apoptotic Sertoli cell death in hypogonadic(hgn/hgn)rat testes during early postnatal development

作     者：MioYagi KatsushiSuzuki HirotesuSuzuki 

作者机构：Department of Veterinary PhysiologyNippon Veterinary and Life Science UniversityTokyo 180-8602Japan 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2006年第8卷第5期

页      面：535-541页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：apoptosis hgn/hgn male hypogonadism Sertili cell testis TUNEL vimentin 

摘      要：Aim： To determine the involvement of apoptotic cell death in postnatal pathogenesis in mutant strain of hypogonadic （hgn/hgn） rats testes. We evaluated the numbers and types of cells undergoing apoptotic cell death. Methods： Tissue sections were stained by the TUNEL method for in situ detection of apoptotic cells, with specific antibodies used as markers of testicular somatic and germ cells. Results： We found that apoptosis in the hgn/hgn testes during the early postnatal period occurred primarily in Sertoli cells, which should actively proliferate during this stage of differentiation. These findings strongly suggest that the normal allele of hgn is involved in the direct or indirect control of differentiation and proliferation of Sertoli cells. Conclusion： To our knowledge, this is the first report demonstrating early postnatal apoptosis of Sertoli cells, suggesting that the hgn/hgn rat is a unique model for the study of Sertoli cell deficiency.