Effect of Urena lobataleaves extract on the improvements of lipid profiles on diabetic rats

作     者：Triari NIZUAR Eko BAGUS Yudi PURNOMO 

作者机构：School of Medicine Malang Islamic University Indonesia 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2015年第29卷第S1期

页      面：117-118页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The project supported by Ministry Education of Indonesia 

主　　题：U.lobata diabetic rat profiles lipid TC TG LDL HDL 

摘      要：OBJECTIVE To investigate effect of *** extract on the improvement of lipid profiles on diabetic *** This study uses control group post test only with male Sprague dawley *** rats was induced by high fructose diet(HFD)and single dose streptozotocin 25mg·kg-1 bw intra *** rat was administrated orally with water extract of *** in dose of 250,500 and 1000mg·kg-1 bw for *** scarifying,blood sample was collected and then total cholesterol(TC)serum level,triglyceride(TG),low density lippoprotein(LDL)and high density lipoprotein(HDL)were *** data was analyzed using ANOVA test continued with LSD test(P0.05).RESULTS The supplementation of water extract from *** dose of 250,500 and 1000mg·kg-1 bw decrease TC serum level approximately 15%,25% and 35% compared to diabetic group(P0.05),whereas the TG was decreased by 10%,20% and 30%(P0.05)*** oral administration of *** extract 250,500 and 1000mg·kg-1 bw also were able to decrease LDL serum level about 30%,60% and 90%respectively compared to diabetic group(P0.05),while the HDL serum level was increased by 40%,80% and 100%(P0.05)*** diabetic groups,HDL level serum was decreased compared to normal group(P0.05)while the TC,TG and HDL were increased(P0.05).CONCLUSION *** leaves extract could repair lipid profiles of diabetic rats by increasing of HDL serum level,decreasing of TC serum level,TG and *** potency may be related to active substances which act as an anti-cholesterolemia and antioxidant in *** extract.