胆管闭锁婴儿术前可溶性黏附分子的状况
Soluble adhesion molecule profiling in preoperative infants with biliary atresia作者机构：Department of Paediatric Surgery Kings College Hospital SE5 9RS London United Kingdom
出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)
年 卷 期：2006年第2卷第2期
页 面：46-47页
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100204[医学-神经病学] 10[医学]
主 题：可溶性黏附分子 胆管闭锁 手术前 婴儿 细胞间黏附分子 酶联免疫吸附法 sICAM-1 细胞黏附因子 对数回归分析 辅助因子
摘 要：Objective: Intercellular adhesion molecule (ICAM) expression in liver and bile duct remnant is a feature of the inflammatory component of biliary atresia (BA). Circulating levels of such soluble adhesion molecules (SAM) should reflect intrahepatic disease and would prove a useful adjunct in the evaluation of BA. Study Design: Serum ICAM-1 (sICAM-1), serum vascular cell adhesion mol-ecule (sVCAM-1), and serum E selectin (sE-selectin) were measured by enzyme-linked immunosorbent assay in infants with BA at the time of portoenterostomy and stratified by outcome. Results are quoted as medians (range). Binary logistic regression analysis and actuarial survival curves were used to investigate the relationship of SAM profile to outcome. Significance was assumed at P values of ≤ .05. Results: Sixty-one infants with BA were treated between 1996 and 2002 and at follow-up; 39 of these were alive and jaundice-free (good outcome, n=39); 21 had been transplanted, and 1 died (poor outcome, n=22). Preoperative values for sICAM-1 were 1233 (400-2000) ng/mL; sVCAM-1, 1204(517-1921) ng/mL; and sE-selectin, 71(26-192) ng/mL. sVCAM-1(P1380 ng/mL) showed a significantly worse actuarial survival (P = .05). Conclusion: Levels of sICAM-1 and sVCAM-1 are grossly elevated in BA, whereas sE-selectin levels are normal. Only sVCAM-1 levels have prognostic signi
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