Identification of a combination of SNPs associated with Graves' disease using swarm intelligence

作     者：WEI Bin PENG QinKe ZHANG QuanWei LI ChenYao 

作者机构：State Key Laboratory for Manufacturing Systems Engineering and School of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China MOE Key Laboratory for Intelligent Networks and Network SecurityXi’an Jiaotong UniversityXi’an 710049China Electronic and Information School of Xi’an Jiaotong UniversityXi’an 710049China 

出 版 物：《Science China(Life Sciences)》 (中国科学(生命科学英文版))

年 卷 期：2011年第54卷第2期

页      面：139-145页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (Grant No. 60774086) the Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20090201110027) 

主　　题：Graves' disease single nucleotide polymorphism case-control study swarm intelligence 

摘      要：Graves disease,the production of thyroid-stimulating hormone receptor-stimulating antibodies leading to hyperthyroidism,is one of the most common forms of human autoimmune *** is widely agreed that complex diseases are not controlled simply by an individual gene or DNA variation but by their *** nucleotide polymorphisms(SNPs),which are the most common form of DNA variation,have great potential as a medical diagnostic *** this paper,the P-value is used as a SNP pre-selection criterion,and a wrapper algorithm with binary particle swarm optimization is used to find the rule for discriminating between affected and control *** analyzed the association between combinations of SNPs and Graves disease by investigating 108 SNPs in 384 cases and 652 *** evaluated our method by differentiating between cases and controls in a five-fold cross validation test,and it achieved a 72.9% prediction accuracy with a combination of 17 *** experimental results showed that SNPs,even those with a high P-value,have a greater effect on Graves disease when acting in a combination.