Mediator Complex Dependent Regulation of Cardiac Development and Disease

作     者：Chad E. Grueter 

作者机构：Division of Cardiovascular Medicine Department of Internal Medicine University of Iowa Carver College of Medicine 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2013年第11卷第3期

页      面：151-157页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the American Heart Association(Grant No. 13SDG14660064) 

主　　题：Mediator complexCardiac disease Transcription Development 

摘      要：Cardiovascular disease （CVD） is a leading cause of morbidity and mortality. The risk factors for CVD include environmental and genetic components. Human mutations in genes involved in most aspects of cardiovascular function have been identified, many of which are involved in transcriptional regulation. The Mediator complex serves as a pivotal transcriptional reg- ulator that functions to integrate diverse cellular signals by multiple mechanisms including recruit- ing RNA polymerase II, chromatin modifying proteins and non-coding RNAs to promoters in a context dependent manner. This review discusses components of the Mediator complex and the contribution of the Mediator complex to normal and pathological cardiac development and func- tion. Enhanced understanding of the role of this core transcriptional regulatory complex in the heart will help us gain further insights into CVD.