Effectiveness of Jinying capsule on pelvic inflammatory disease in patients with symptom pattern of damp and heat accumulation: a double-blinded, multicenter, randomized, placebo-controlled clinical trial

作     者：Yang Yan Lu Yao Zhou Deping Pei Fenglan Li Qin Chen Shuqiong Wang Qiufeng Wang Yanting Jin Zhe Liu Yanxia Yang Yan;Lu Yao;Zhou Deping;Pei Fenglan;Li Qin;Chen Shuqiong;Wang Qiufeng;Wang Yanting;Jin Zhe;Liu Yanxia

作者机构：Department of GynecologyDongfang Hospital of Beijing University of Chinese MedicineBeijing 100078China Department of Clinical Pharmacological BaseDongfang Hospital of Beijing University of Chinese MedicineBeijing 100078China Department of Emergency GynecologyChongqing health center for women and childrenChongqing 401147China Department of Obstetrics and GynecologyChinese medicine hospital of HandanHebei 056000China Department of Gynecology and Reproductive MedicineThe secondary hospital affiliated to Shanxi university of Chinese MedicineShanxi 712000China Department of GynecologyHunan Health Center for Women and ChildrenChangsha 410008China Department of Obstetrics and GynecologyChinese medicine hospital of LuoheLuohe 462000China Department of ObstetricsPeople's Hospital of XinzhouXinzhou 034000China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2020年第40卷第3期

页      面：432-439页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Department of Gynecology, Dongfang Hospital of Beijing University of Chinese Medicine Beijing University of Chinese Medicine, BUCM 

主　　题：Pelvic inflammatory disease Dampness-heat Therapeutic uses Safety Randomized controlled trial Double-blind method Jinying capsule 

摘      要：OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Traditional Chinese Medicine(TCM).METHODS: We conducted a double-blinded, multicenter, randomized, placebo-controlled clinical trial which included 155 patients diagnosed with PID and identified as symptom pattern of damp and heat accumulation. They were randomly divided into experimental group(n = 78) and control group(n = 77) according to a random number table. The treatment lasted for a period of 28 d. The experimental group was given Jinying capsules and oral levofloxacin plus oral metronidazole for first 7 *** continued with Jinying capsules and levofloxacin placebo and metronidazole placebo for another 7 d. For the remaining 14 d, they continued with Jinying capsules only. Whereas, the control group was treated with oral levofloxacin and metronidazole and Jinying capsule placebo for the first 14 d in the same way as the experimental group and then continued with Jinying capsule placebo only for the remaining 14 d. The clinical efficacy was assessed using McCormack scale, TCM symptom pattern scores, physicochemical indexes including white blood cell and erythrocyte sedimentation rate, C-reaction protein, smear of vaginal discharge,and pelvic ***: Comparing McCormack scale between both groups after treatment, the difference in curative effect between both groups was significant (P = 0.0269). The cure rate of the experimental group and control group is 76.32% and 59.46% respectively at week 4. Comparing TCM symptom pattern scores between both groups before and after treatment, the differences in total effective rate were both significant(P 0.05). The curative effect rate of experimental group is 2.63% and 13.70% of the control group at week 1(P = 0.0131), and73.33% of the experimental group and 56.94% of the control group at week 4(P